Jill P. Mesirov
Also known as Jill P. Mesirov-Kazdan
Jill Mesirov is a mathematician and computational biologist who applies machine learning to cancer genomics and builds free software for genomic analysis. Trained in mathematics at the University of Pennsylvania and Brandeis, where she earned her doctorate in 1974, she directed research at Thinking Machines Corporation and managed computational biology at IBM before joining the Whitehead Institute of MIT in 1997. At the Broad Institute of MIT and Harvard she became associate director and chief informatics officer, and she coauthored the 2005 paper introducing Gene Set Enrichment Analysis and the 2011 paper on the Integrative Genomics Viewer. She moved to UC San Diego in 2015 as associate vice chancellor for computational health sciences. Since July 2026, she is a Distinguished Professor and Senior Vice President for Computational Science at Sanford Burnham Prebys, where her duties include advancing the institute's use of artificial intelligence.
- Now at
- Sanford Burnham Prebys Medical Discovery Institute
- Badges
Timeline
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1974
A Brandeis doctorate in mathematics
She earns a BA in mathematics at the University of Pennsylvania, then an MA and a PhD in mathematics at Brandeis University. Her doctorate, supervised by Richard Palais, comes in 1974.
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1989–1996
President of the AWM
She serves as president of the Association for Women in Mathematics from 1989 to 1991. In 1996, she becomes a fellow of the American Association for the Advancement of Science.
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By 1997
Thinking Machines and IBM
Before 1997, she holds posts in the mathematics department at UC Berkeley and at the Institute for Defense Analyses, where she conducts work in cryptology and speech. She also serves as associate executive director of the American Mathematical Society, director of research at Thinking Machines Corporation, and manager of computational biology and bioinformatics in IBM's Healthcare/Pharmaceutical Solutions Organization.
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1997–2015
Whitehead and the Broad Institute
She joins the Whitehead Institute of MIT in 1997, which later becomes part of the Broad Institute of MIT and Harvard. At the Broad, she serves as associate director and chief informatics officer and directs the Computational Biology and Bioinformatics Program until she leaves for UC San Diego in 2015.
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2005–2011
GSEA and the Integrative Genomics Viewer
In 2005, she coauthors the PNAS paper introducing Gene Set Enrichment Analysis (GSEA) with Aravind Subramanian, Pablo Tamayo, Eric Lander and others; the method reads gene expression data through sets of genes that share biological function and comes as a freely available software package. In 2011, she publishes the Integrative Genomics Viewer in Nature Biotechnology with James T. Robinson, Helga Thorvaldsdóttir, Gad Getz and colleagues.
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2012
ISCB and AMS fellowships
The International Society for Computational Biology names her to its Fellows Class of 2012. In 2012, she also becomes one of the inaugural fellows of the American Mathematical Society.
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2015–2026
Associate vice chancellor at UC San Diego
In June 2015, UC San Diego appoints her associate vice chancellor for computational health sciences and professor of medicine at the School of Medicine and Moores Cancer Center. Her group applies machine-learning methods to functional genomics data in cancer and infectious disease, and in October 2015 the Department of Computer Science and Engineering names her a faculty affiliate.
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Since July 2026
Senior vice president at Sanford Burnham Prebys
She joins Sanford Burnham Prebys Medical Discovery Institute in July 2026 as a Distinguished Professor and Senior Vice President for Computational Science. Her duties include shaping computational science strategy and advancing the rapid development and use of artificial intelligence, and she is a member of the institute's Center for Data Science and Artificial Intelligence.
Career
- Since 2026Sanford Burnham Prebys Medical Discovery InstituteDistinguished Professor; Senior Vice President for Computational Science
- Until 2015Broad InstituteAssociate Director; Chief Informatics Officer
- 2015–2026University of California, San DiegoAssociate Vice Chancellor for Computational Health Sciences
- From 1997Massachusetts Institute of Technology
- Thinking Machines CorporationDirector of Research
- IBMManager of Computational Biology and Bioinformatics
Education
Sources and credits
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- Jill P. Mesirov - Wikipedia
- Jill Mesirov - UC San Diego Health Sciences leadership
- Jill P. Mesirov Appointed Associate Vice Chancellor for Computational Health Sciences
- Pioneering computer biologist Jill Mesirov joins Sanford Burnham Prebys
- Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles - PMC
- IGV Desktop Application
- The International Society for Computational Biology names seven members as the ISCB Fellows Class of 2012
- Computational Biologist Faculty-Affiliate Joins UC San Diego | Computer Science
- Jill P. Mesirov, PhD - Sanford Burnham Prebys





