Researcher

John McCaskill

Also known as John S. McCaskill, John Simpson McCaskill

John McCaskill is an Australian chemist whose work on evolving molecular information systems runs from RNA folding and artificial cells to DNA computing and communicating microrobots. After a 1982 D.Phil. at Oxford as a Rhodes Scholar, he led an evolutionary self-organization group in Manfred Eigen's department in Göttingen, and in 1990 he published an ensemble approach to RNA folding that is now in wide use. He became a professor of theoretical biochemistry at Jena in 1992, co-edited the Artificial Life VII proceedings in 2000, and coordinated the EU artificial-cell projects PACE, ECCell and MICREAgents after moving his BioMIP group to Ruhr University Bochum in 2004. In 2005, the PACE consortium founded the European Centre for Living Technology in Venice with him as a founding director. He joined TU Chemnitz's MAIN research center in August 2022 and co-authored a 2025 Science Robotics paper on smartlets, millimeter-sized microrobots that communicate by light; today he leads the center's Microelectronic Biosystems research group.

Now at
Chemnitz University of Technology and European Centre for Living Technology
Born
1957
Works
186
Citations
5,395
h-index
27

Years link to their sources. Publication numbers from OpenAlex, as of 22 October 2026.

Timeline

  1. 1957–1982

    Rhodes Scholar at Oxford

    Born in Sydney in 1957, he studies chemistry, physics and mathematics at the Universities of Sydney and Oxford. He graduates from Sydney University in 1978 under advisor R. G. Gilbert and completes a D.Phil. in 1982 as a Rhodes Scholar at New College, Oxford.

  2. 1987–1992

    Evolution with Manfred Eigen

    From 1987, he leads a research group in evolutionary self-organization affiliated with Nobel laureate Manfred Eigen's department at the Max Planck Institute for Biophysical Chemistry in Göttingen. In 1990, he publishes a method for the equilibrium partition function and base-pair binding probabilities of RNA secondary structure, an ensemble approach to RNA folding now in wide use.

  3. 1992–1999

    Professor in Jena

    He becomes full professor of theoretical biochemistry at the University of Jena in 1992 and founds the first Department for Molecular Information Processing at the Institute for Molecular Biotechnology. His Jena group builds spatially resolved molecular information systems with simulation, microfluidics and reconfigurable electronics, and in 1997 he contributes “VLSE: Very Large Scale Evolution in Hardware” to the Fourth European Conference on Artificial Life.

  4. 1999–2004

    BioMIP at the GMD

    In 1999, he moves his group to the German National Research Center for Information Technology (GMD) in Sankt Augustin near Bonn as Biomolecular Information Processing (BioMIP). In 2000, he co-edits Artificial Life VII, the MIT Press proceedings of the seventh international conference on artificial life, with Mark A. Bedau, Norman H. Packard and Steen Rasmussen. From 2000, he develops a chemical microprocessor technology for electronically programmable matter via microscale electrochemistry.

  5. 2004–2008

    Coordinating the PACE project

    He coordinates PACE (Programmable Artificial Cell Evolution), a 2004–2008 EU project with 16 partners and one of the earliest bottom-up efforts to create an artificial living cell, and moves BioMIP to the Ruhr University Bochum in 2004. In 2005, the PACE consortium establishes the European Centre for Living Technology in Venice, with McCaskill among its founding directors.

  6. 2009–2018

    MICREAgents and lablets in Bochum

    In 2009, BioMIP moves to labs on the Ruhr University Bochum campus, where it runs until 2017 in the Faculty of Chemistry and Biochemistry and coordinates the EU projects ECCell and MICREAgents. In 2012, MICREAgents wins first place in an EU call on unconventional computing and receives 3.4 million euros to build lablets, self-assembling electronic microreagents almost as small as cells. In 2018, he prepares a scientific and technical roadmap for nanorobotic surgery for the University of Sydney.

  7. 2022–2025

    Smartlets at TU Chemnitz

    He joins the Research Center MAIN at TU Chemnitz in August 2022, and in 2023, as a founding director and science board member of the European Centre for Living Technology, he welcomes TU Chemnitz into the ECLT network. In 2025, he is a co-corresponding author of a Science Robotics paper on smartlets, millimeter-sized microrobots that communicate by light and carry lablet chiplets from an EU project he led.

  8. As of October 2026

    Microelectronic Biosystems group leader

    As of October 2026, he leads the Microelectronic Biosystems research group at TU Chemnitz's Research Center MAIN.

Career

  1. Since 2022Chemnitz University of TechnologyMicroelectronic Biosystems research group leader
  2. 2005–2022European Centre for Living TechnologyFounding director and science board member
  3. 2004–2017Ruhr University BochumBioMIP group leader
  4. 2001–2004Fraunhofer-Gesellschaft
  5. 1999–2004German National Research Center for Information TechnologyBioMIP group leader
  6. 1992–1999Friedrich Schiller University JenaProfessor of Theoretical Biochemistry
  7. From 1992Institute for Molecular BiotechnologyFounder
  8. 1988–1997Max Planck Society
  9. 1987–1992Max Planck Institute for Multidisciplinary SciencesResearch group leader

Education

  1. 1982University of OxfordD.Phil.
  2. 1978University of Sydney

Most-cited works

  1. The equilibrium partition function and base pair binding probabilities for RNA secondary structure1990 · Biopolymers · 1,311 citations
  2. Molecular quasi-species1988 · The Journal of Physical Chemistry · 668 citations
  3. Open Problems in Artificial Life2000 · Artificial Life · 298 citationsWith Chris Adami, Mark Bedau and Norman Packard
  4. Monte Carlo approach to tissue-cell populations1995 · Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics · 178 citations
  5. Artificial Life VII2000 · The MIT Press eBooks · 129 citationsWith Mark Bedau

Sources and credits

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  1. John McCaskill - Wikipedia en.wikipedia.org. Checked 20 October 2026.
  2. Profile | John Simpson McCaskill biomip.org. Checked 20 October 2026.
  3. BioMIP History | John Simpson McCaskill biomip.org. Checked 20 October 2026.
  4. Electronic Chemical Micro and Nanosystems | John Simpson McCaskill biomip.org. Checked 20 October 2026.
  5. SS > book reviews > John S. McCaskill www-users.york.ac.uk. Checked 20 October 2026.
  6. PACE | John Simpson McCaskill biomip.org. Checked 20 October 2026.
  7. Foundation of a Center for Living Technology | PACE REPORT | John McCaskill biomip.org. Checked 20 October 2026.
  8. Turning chemistry inside-out chemeurope.com. Checked 20 October 2026.
  9. TU Chemnitz in internationales Netzwerk für „Living Technologies“ aufgenommen | TUCaktuell | TU Chemnitz tu-chemnitz.de. Checked 20 October 2026.
  10. Smart Microrobots Learn to Communicate and Collaborate in Water idw-online.de. Checked 20 October 2026.
  11. Members and Contributors | Research Center MAIN | MAIN | TU Chemnitz tu-chemnitz.de. Checked 20 October 2026.