Ryan Flynn
Also known as Ryan A. Flynn
Ryan Flynn is a chemical biologist at Boston Children's Hospital and Harvard who studies RNA on the cell surface and used Google DeepMind's AI Co-Scientist in a 2026 ALS research collaboration. A biology graduate of MIT, they completed an M.D. and Ph.D. at Stanford in 2017 and, as a postdoctoral fellow in Carolyn Bertozzi's lab, reported glycoRNAs, small RNAs coated with sugars, in a 2021 Cell paper. After starting an independent lab at Boston Children's Hospital in 2021, they received an NIH Director's Transformative Research Award in 2024 and the Glycobiology Significant Achievement Award in 2025. In May 2026, Google DeepMind described how Co-Scientist helped Ritu Raman of MIT and Flynn combine tissue models with RNA biology in a search for RNA-based approaches to ALS. They are an Associate Professor in the Stem Cell Program at Boston Children's Hospital and in Harvard's Department of Stem Cell and Regenerative Biology.
- Now at
- Boston Children's Hospital and Harvard University
- Works
- 128
- Citations
- 21,656
- h-index
- 50
Publication numbers from OpenAlex, as of 22 October 2026.
Timeline
-
2010–2017
MIT and a Stanford MD/PhD
They graduate from MIT in 2010 with a B.S. in biology, where they first learn RNA biology deeply under Phil Sharp's mentorship. They complete an M.D. and Ph.D. in cancer biology in Stanford's Medical Science Training Program in 2017, mentored by Howard Chang.
-
2017–2021
Postdoc with Carolyn Bertozzi
Trained in RNA biology, they join Carolyn Bertozzi's glycoscience lab at Stanford as a postdoc in 2017. In 2021, they move to Harvard to establish an independent laboratory in the Stem Cell Program at Boston Children's Hospital.
-
2021
The glycoRNA discovery
With Bertozzi, they publish "Small RNAs are modified with N-glycans and displayed on the surface of living cells" in Cell in 2021. The paper reports glycoRNAs, small noncoding RNAs coated with N-glycans and found on the cell surface.
-
August 2024
How RNA attaches to glycans
In August 2024, Cell publishes work from their lab that identifies the mechanism by which RNA is chemically linked to N-glycans, with the modified base acp3U as an attachment site. The work shows that glycoconjugates fall into three classes: proteins, lipids and RNAs.
-
2024
An NIH Transformative Research Award
In 2024, they receive an NIH Director's Transformative Research Award to explore how RNA and RNA-binding proteins function on the surface of cells.
-
2025
Glycobiology Significant Achievement Award
In 2025, they win the Glycobiology Significant Achievement Award.
-
May 2026
Co-Scientist and ALS research
In May 2026, Google DeepMind describes how Co-Scientist, its multi-agent AI partner for research, helped MIT's Ritu Raman test ALS evidence against her tissue model and rank research directions. The system's strongest leads concerned communication at the cell surface, so Raman brings them to Flynn, a chemical biologist who maps RNA on the surface of cells, and the pair use Co-Scientist iteratively to search for RNA-based mechanisms and potential RNA-based drugs against ALS. DeepMind's Co-Scientist announcement also thanks them among its research collaborators.
-
As of October 2026
Associate Professor at Harvard
They are an Associate Professor in the Stem Cell Program at Boston Children's Hospital and in the Department of Stem Cell and Regenerative Biology at Harvard, and principal faculty at the Harvard Stem Cell Institute. Their lab, established in 2021, studies RNA glycosylation and cell surface RNA-binding proteins, including how cell surface RNAs regulate signalling by the growth factor VEGF-A165.
Career
- Since 2021Boston Children's HospitalAssociate Professor
- Since 2021Harvard UniversityAssociate Professor
- 2017–2021Stanford UniversityPostdoctoral fellow
Education
- 2010Massachusetts Institute of TechnologyB.S. in biology
Most-cited works
- A unique chromatin signature uncovers early developmental enhancers in humans
- A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression
- c-Myc Regulates Transcriptional Pause Release
- m6A RNA Modification Controls Cell Fate Transition in Mammalian Embryonic Stem Cells
- HiChIP: efficient and sensitive analysis of protein-directed genome architecture
Sources and credits
Photo: We have no published photo of Ryan Flynn yet. Send us a free-licensed photo.
- Ryan Flynn, M.D., Ph.D. | HSCRB
- Ryan Flynn | Boston Children's Research
- Some RNA Molecules Have Unexpected Sugar Coating | HHMI
- Discovery of sugar-coated RNA molecules opens up new area of cell biology | HSCRB
- Unveiling GlycoRNA: New Study Proves They Do Exist | HSCRB
- Environmental Factor - November 2024: NIH awards High Risk, High Reward research grants
- Past Sig Achievement Award Winners
- Co-Scientist: Driving creative collaboration to accelerate ALS research — Google DeepMind
- Co-Scientist: A multi-agent AI partner to accelerate research — Google DeepMind
- Flynn Lab – BCH
