Frederik Maes
Frederik Maes is a medical-image computing researcher whose work spans brain MRI, medical image analysis and clinical AI. He coauthored methods for tracking brain MRI lesions, increasing MR spectroscopy resolution, and comparing deep-learning algorithms for COVID-19 CT images. Later work applied AI to knee-replacement planning and developed confidence-aware estimates for ratio-based biomarkers; by 2025, his publication record included at least 140 papers. As of October 2026, he researches medical imaging with KU Leuven’s ESAT/PSI and UZ Leuven’s Medical Imaging Research Center, including a deep-learning pipeline for micro-CT airway analysis.
Timeline
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2016
MSmetrix-long lesion segmentation
In 2016, he coauthors MSmetrix-long, a joint expectation-maximization framework for segmenting white-matter lesions across two time points in brain MRI.
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2017
Super-resolution for MRSI
In 2017, he coauthors a patch-based method that increases the spatial resolution of metabolite maps from magnetic resonance spectroscopic imaging.
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2020
Deep learning for COVID-19 CT
In 2020, he coauthors a study comparing twelve deep-learning algorithms for automatic segmentation of lungs, lesions and lesion types in CT scans from COVID-19 patients.
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2022
AI knee replacement planning
In 2022, he coauthors an AI-driven planning study for total knee arthroplasty that evaluates surgeon- and patient-specific preoperative plans requiring fewer changes by the surgeon.
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2025
Confidence-aware biomarkers
In 2025, he coauthors a unified confidence-aware framework for estimating ratio-based biomarkers.
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By 2025
At least 140 papers
By 2025, his publication record spans at least 140 papers, with work dating back to 1995.
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As of October 2026
Medical imaging at KU Leuven
He is affiliated with KU Leuven’s ESAT/PSI and UZ Leuven’s Medical Imaging Research Center. In August 2026, he coauthors an automated deep-learning pipeline for 3D characterization of the murine upper airway from micro-CT.
Career
- Since 1995KU LeuvenResearcher
- NowUZ LeuvenResearcher
- 2013–2016IMEC
- 2009–2012HOGENT University of Applied Sciences and Arts
- 2009–2012Ghent University
Sources and credits
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- Two Time Point MS Lesion Segmentation in Brain MRI: An Expectation-Maximization Framework
- Patch-Based Super-Resolution of MR Spectroscopic Images
- Comparative study of deep learning methods for the automatic segmentation of lung, lesion and lesion type in CT scans of COVID-19 patients
- Artificial Intelligence Based Patient-Specific Preoperative Planning Algorithm for Total Knee Arthroplasty
- Beyond Segmentation: Confidence-Aware and Debiased Estimation of Ratio-based Biomarkers
- Frederik Maes
- An automated deep learning-based pipeline for 3D characterisation of the murine upper airway from micro-CT



