Researcher

Lucila Ohno-Machado

Also known as Lucila Ohno‐Machado

Lucila Ohno-Machado is a physician and biomedical informatician whose work spans neural network models for survival analysis and federated algorithms that build predictive models while patient data stay local. She grew up in Brazil, earned her medical degree at the University of São Paulo, and completed a Stanford PhD in medical information sciences and computer science in 1996. After moving to Boston in 1997, she became founding chief of the Division of Biomedical Informatics at UC San Diego in 2009, edited the Journal of the American Medical Informatics Association from 2011 to 2018, and coauthored the GLORE method in 2012. The National Academy of Medicine elected her in 2018, while she chaired the Department of Biomedical Informatics at UC San Diego Health. She joined Yale School of Medicine in January 2023 and is now deputy dean for biomedical informatics and chair of its Department of Biomedical Informatics and Data Science, whose faculty teach the school's online Master of Health Science in Medical AI.

Now at
Yale School of Medicine
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Timeline

  1. By 1996

    From São Paulo to Stanford

    She grows up in Brazil, earns her medical degree at the University of São Paulo, and becomes one of the first residents in its new medical informatics residency. She completes a PhD in medical information sciences and computer science at Stanford University in 1996, with thesis work on neural network models for survival analysis.

  2. 1997–2009

    Professor at Harvard–MIT

    In 1997, she moves to the Boston area as a professor in the Department of Radiology and the Division of Health Sciences and Technology at Harvard–MIT. She holds a distinguished chair in biomedical informatics at Brigham and Women's Hospital, with faculty roles at Harvard Medical School and MIT's Health Sciences and Technology Division.

  3. 2009–2022

    A new division at UC San Diego

    In 2009, she founds the Biomedical Informatics program at UC San Diego School of Medicine as founding chief of its Division of Biomedical Informatics, and it becomes a department at UC San Diego Health in 2015. As founding chair of the University of California Research eXchange (UC ReX), which starts in 2011 across the five UC medical centers, she helps build a system that searches more than 15 million de-identified patient records with one query. She resigns as division chief in November 2022 to join a new initiative with Yale University.

  4. 2011–2018

    Editor of JAMIA

    In 2010, the board of the American Medical Informatics Association selects her as the new editor-in-chief of its journal, JAMIA, with a term that starts in January 2011. She writes her final editorial as editor in 2018.

  5. 2012

    The GLORE federated model

    In 2012, she coauthors GLORE (Grid Binary LOgistic REgression) with Yuan Wu, Xiaoqian Jiang and Jihoon Kim in the Journal of the American Medical Informatics Association. The method sends the computation to each site's data and produces a logistic regression model that matches one fitted on the combined data, part of her work on algorithms that build multivariate models in a federated manner while data stay local.

  6. 2018

    Election to the National Academy of Medicine

    In October 2018, she is elected to the National Academy of Medicine while chair of the Department of Biomedical Informatics at UC San Diego Health. She also co-leads the California Precision Medicine Consortium, which manages the All of Us Research Program in California.

  7. January 2023

    Joining Yale School of Medicine

    She joins Yale School of Medicine in January 2023 as inaugural chair of the Section of Biomedical Informatics and Data Science and deputy dean for biomedical informatics, with an appointment as Waldemar von Zedtwitz Professor. In this role she oversees the infrastructure related to biomedical informatics research across the academic health system.

  8. As of October 2026

    Chair of Yale's informatics department

    Yale's Section of Biomedical Informatics & Data Science becomes the Department of Biomedical Informatics & Data Science, with her as inaugural chair, and its members develop the computational infrastructure to employ AI in a secure, privacy-protecting manner. In August 2026, Yale School of Medicine announces a new online Master of Health Science in Medical AI, taught by faculty from her department.

Career

  1. Since 2023Yale School of MedicineDeputy dean for biomedical informatics, Inaugural chair
  2. From 2018UC San Diego HealthChair
  3. From 2018California Precision Medicine ConsortiumCo-lead
  4. From 2011University of California Research eXchangeFounding chair
  5. 2009–2022University of California San Diego School of MedicineFounding chief
  6. 1997–2009Harvard Medical SchoolProfessor
  7. 1997–2009Massachusetts Institute of TechnologyProfessor
  8. 1997–2009Mass General BrighamDistinguished chair in biomedical informatics

Education

  1. 1996Stanford UniversityPhD
  2. Universidade de São PauloMedical degree

Sources and credits

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  1. Building a Program at the Intersection of Computer Science and Medicine: Meet Lucila Ohno-Machado | Yale School of Medicine medicine.yale.edu. Checked 21 October 2026.
  2. Lucila Ohno-Machado - Connecticut Academy of Science and Engineering ctcase.org. Checked 21 October 2026.
  3. Ohno-Machado appointed von Zedtwitz Professor at Yale School of Medicine | Yale News news.yale.edu. Checked 21 October 2026.
  4. Lucila Ohno-Machado - Wikipedia en.wikipedia.org. Checked 21 October 2026.
  5. History - Division of Biomedical Informatics, UC San Diego School of Medicine dbmi.ucsd.edu. Checked 21 October 2026.
  6. UC San Diego Health's Lucila Ohno-Machado Elected to National Academy of Medicine today.ucsd.edu. Checked 21 October 2026.
  7. UC ReX - Division of Biomedical Informatics, UC San Diego School of Medicine dbmi.ucsd.edu. Checked 21 October 2026.
  8. New Editor-in-Chief Named to Lead JAMIA | Newswise newswise.com. Checked 21 October 2026.
  9. Reflections on the journey of editing a scientific journal - PMC pmc.ncbi.nlm.nih.gov. Checked 21 October 2026.
  10. Grid Binary LOgistic REgression (GLORE): building shared models without sharing data - PMC pmc.ncbi.nlm.nih.gov. Checked 21 October 2026.
  11. Lucila Ohno-Machado, MD, MBA, PhD | Yale School of Medicine medicine.yale.edu. Checked 21 October 2026.
  12. New Department of Biomedical Informatics & Data Science Established at Yale medicine.yale.edu. Checked 21 October 2026.
  13. Yale School of Medicine Launches New Online Master of Health Science in Medical AI medicine.yale.edu. Checked 21 October 2026.