PeopleofSuperintelligence

Researcher

Brian Hie

Brian Hie is a researcher who applies machine learning to the design and modeling of proteins and genomes. He earned a computer science degree at Stanford and graduate degrees at MIT, then used language models to study viral and protein evolution. His work includes protein inverse folding and the genome models Evo and Evo 2. As of October 2026, he is a Stanford chemical engineering assistant professor, an Arc Institute Innovation Investigator, and supervisor of the Laboratory of Evolutionary Design.

Now at
Stanford University and ARC Institute
Badges

Timeline

  1. 2016–2021

    Stanford and MIT degrees

    He earns a computer science bachelor's degree at Stanford in 2016, an EECS master's at MIT in 2019, and an EECS PhD at MIT in 2021.

  2. By 2021

    A science fellowship and software roles

    He is in Stanford Science Fellows' 2021 cohort and has worked as a software engineer for Google X, Salesforce, and Illumina.

  3. 2021

    Language models for viral escape

    He coauthors a Science paper that uses machine learning methods developed for natural language to model viral escape.

  4. By 2022

    Protein evolution at Meta AI

    As a Stanford Science Fellow and visiting researcher at Meta AI, he applies natural-language machine learning and protein language models to study protein evolution.

  5. 2022

    Inverse folding with 12 million structures

    He coauthors a paper that predicts protein sequences from backbone atom coordinates. The team augments training with structures predicted for 12 million protein sequences using AlphaFold2.

  6. 2024

    Evo for genome-scale modeling

    Arc Institute, Stanford, and TogetherAI researchers introduce Evo, a long-context model for prediction and generative design across DNA, RNA, and proteins; Hie is among its contributors.

  7. 2025

    Co-authoring Evo 2

    In 2025, he is an Innovation Investigator in Residence at Arc Institute and an assistant professor of chemical engineering at Stanford. He is a co-senior author of Evo 2, a genomic model trained across all domains of life.

  8. As of October 2026

    Leading the Evolutionary Design Lab

    He is an assistant professor of chemical engineering at Stanford, a Stanford Data Science faculty fellow, and an Innovation Investigator at Arc Institute. He supervises the Laboratory of Evolutionary Design, which studies biology and machine learning.

Career

  1. Since 2025Stanford UniversityAssistant Professor of Chemical Engineering
  2. Since 2025ARC InstituteInnovation Investigator in Residence
  3. GoogleSoftware Engineer
  4. SalesforceSoftware Engineer
  5. IlluminaSoftware Engineer
  6. MetaVisiting Researcher

Education

  1. 2021Massachusetts Institute of TechnologyEECS PhD
  2. 2019Massachusetts Institute of TechnologyEECS master's degree
  3. 2016Stanford UniversityBachelor's degree in computer science

From the biography.

Videos

YouTube videos in which Brian Hie speaks or appears, newest first. A model chose them from YouTube search results. List updated 21 October 2026.

  1. The Evolution Revolution: Scouting Frontiers in AI for Biology with Brian HieCognitive Revolution "How AI Changes Everything" · 20 September 2024 · 1 h 19 min

Video data from YouTube API Services. By watching you agree to the YouTube Terms of Service. How we use YouTube data.

  1. Of 943 people shaping AI who worked at Google, 446 work there nowIncludes Brian Hie. Our estimates of where the 943 people shaping AI who worked at Google and Google DeepMind work now: 446 at Google and 452 across 278 other organizations.
  2. 84% of people shaping AI with recorded undergraduate and doctoral schools changed institutions for their doctorateIncludes Brian Hie. 84% of people shaping AI with recorded undergraduate and doctoral schools changed institutions for their doctorate. Across 2,116 people with both an undergraduate degree and a doctorate recorded, we trace which undergraduate schools feed which doctoral programs, how often students stay at the same school, and how paths differ by birth-country region.
  3. 20% of people at companies who shape AI also hold a university role, led by Google and Stanford UniversityIncludes Stanford University. We estimate that 539 of the 6,766 people with a known current organization (8%) hold both a university role and a company role, including 20% of people at companies and 13% of people at universities.
  4. Google had the most people shaping AI every year from 2014 to 2025Includes Stanford University. Our estimates of which organizations employed the most people shaping AI each year from 1955 to 2025, tracing the shift from university labs to companies.

Colleagues

People with dated positions at the same organization in the same years.

Sources and credits

Photo: We have no published photo of Brian Hie yet. Send us a free-licensed photo.

  1. Brian Hie | Chemical Engineering cheme.stanford.edu. Checked 20 October 2026.
  2. Brian Hie | Science Fellows stanfordsciencefellows.stanford.edu. Checked 20 October 2026.
  3. Brian Hie's Profile | Stanford Profiles profiles.stanford.edu. Checked 20 October 2026.
  4. Brian Hie | STAT statnews.com. Checked 20 October 2026.
  5. Learning inverse folding from millions of predicted structures proceedings.mlr.press. Checked 20 October 2026.
  6. Evo: DNA foundation modeling from molecular to genome scale | Arc Institute arcinstitute.org. Checked 20 October 2026.
  7. Meet Arc Innovation Investigator in Residence, Brian Hie, who is building deep learning models to design biology across scales | Arc Institute arcinstitute.org. Checked 20 October 2026.
  8. AI can now model and design the genetic code for all domains of life with Evo 2 | Arc Institute arcinstitute.org. Checked 20 October 2026.